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1.
Rev. Soc. Bras. Med. Trop ; 48(4): 445-453, July-Aug. 2015. tab, ilus
Artigo em Inglês | LILACS | ID: lil-755959

RESUMO

Abstract:INTRODUCTION:

The therapeutic scheme of triclabendazole (TCBZ), the recommended anthelmintic against Fasciola hepatica , involves 10mg/kg of body weight administered in a single dose; however, clinical trials in children are scarce. We evaluated the efficacy and tolerability of 2 schemes of TCBZ.

METHODS

: Eighty-four Peruvian children with F. hepatica eggs in their stools were allocated into 2 groups: 44 received 2 dosages of 7.5mg/kg each with a 12-h interval (Group I), and 40 received a single 10-mg/kg dose (Group II). Evaluation of efficacy was based on the presence of eggs in stools, and tolerability was based on the presence of symptoms and signs post-treatment.

RESULTS

: A parasitological cure was obtained in 100% of individuals from Group I and 95% of individuals from Group II. The most common adverse event was biliary colic.

CONCLUSIONS

: The tested scheme was efficacious and tolerable, and it might be an optimal scheme in the region. To the best of our knowledge, this represents the largest series of children treated with TCBZ in a non-hospital setting.

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Assuntos
Adolescente , Animais , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Anti-Helmínticos/administração & dosagem , Benzimidazóis/administração & dosagem , Fasciolíase/tratamento farmacológico , Anti-Helmínticos/efeitos adversos , Benzimidazóis/efeitos adversos , Protocolos Clínicos , Esquema de Medicação , Fasciola hepatica , Fezes/parasitologia , Contagem de Ovos de Parasitas , Peru , Índice de Gravidade de Doença
2.
Rev. gastroenterol. Perú ; 27(1): 31-36, ener.-mar. 2007. tab
Artigo em Espanhol | LILACS, LIPECS | ID: lil-533811

RESUMO

Introducción: La infección causada por F. hepática es endémica en el Perú con un creciente número de áreas endémicas, el reporte de estas es esencial para conocer el impacto de la infección en la población. Objetivo: Reportar la tasa de prevalencia de fasciolosis en zonas donde previamente no se habían detectado casos humanos. Material y métodos: Se estudiaron 3 distritos alrededor de la ciudad de Lima: La Chaqui, provincia de Canta; San Lorenzo de Quinti y San Miguel de Sangallaya, provincia de Huarochirí, pertenecientes al departamento de Lima. Se incluyó a niños y adultos jóvenes (menores de 25 años). Cada muestra de heces se analizó mediante la Técnica de Sedimentación Rápida de Lumbreras. Resultados: La prevalencia global por métodos coprológicos en los tres distritos fue 8.6 por ciento (n=291); 3.9 por ciento (n=102) en La Chaqui, 26.9 por ciento (n=27) en San Miguel de Sangallaya, y 8.6 por ciento (n=163) en San Lorenzo de Quinti. Conclusión: La infección por F. hepática infection es un problema de Salud Pública en pueblos alrededor de la ciudad de Lima. Por lo tanto, las medidas de control y prevención, a parte de ser dirigidas a pobladores autóctono, deben tomar en cuenta grupos de alto riesgo como viajeros frecuentes y personas con regímenes dietéticos basados en vegetales crudos.


Introduction: The infection caused by F. hepatica is endemic in Perú with anincreasing number of endemic areas, the reporting of them is essential to know the impact of the infection in the population. OBJECTIVE: To report the prevalence rate of fascioliasis in areas where it had not been detected human cases previously. MATERIAL AND METHODS: Three districts in Lima department were studied; La Chaqui,province of Canta; San Lorenzo of Quinti and San Miguel of Sangallaya, province of Huarochirí. It included children and young adults (less than 25 years old). One stool sample by person was collected and processed by means of the Rapid Sedimentation Technique described by Lumbreras. RESULTS: Overall, the prevalence rate in the three districts was 8.6 per cent (n=291); 3.9 per cent (n=102) in La Chaqui, 26.9 per cent (n=27) in San Miguel of Sangallaya, and 8.6 per cent (n=163) inSan Lorenzo of Quinti. CONCLUSION: F. hepatica infection is a Health Public problem in populations surrounding Lima city. Therefore, control and prevention measurements, besides being addressed to authoctonus people, should also take into account high-risk groups such as frequent travelers to endemic areas and people with dietetic programs based on raw vegetables.


Assuntos
Humanos , Masculino , Adulto , Criança , Feminino , Parasitologia/métodos , Doenças Endêmicas , Fasciola hepatica , Fasciolíase/epidemiologia , Fasciolíase/prevenção & controle , Estudos Epidemiológicos
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